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Tramadol is generic name of ultram. Ultracet Tablets combines tramadol 37.5 mg and acetaminophen 325 mg.

Tramadol can be considered an atypical opioid analgesic that has a dual action. It is a weak mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin. It is believed that both mechanisms work synergistically to provide analgesic benefit with a potency that is approximately one-tenth that of morphine and approximately equivalent to codeine.

The most common side effects reported with tramadol are drowsiness, constipation, dizziness, nausea, and orthostatic hypotension. There is also a risk of precipitating seizures in patients with a previous history or in patients who are receiving medications that could reduce the seizure threshold. The use of other serotonergic medications (e.g., selective serotonin reuptake inhibitors [SSRIs] and serotonin-norepinephrine reuptake inhibitors [SNRIs]) together with tramadol has the potential to increase the risk of the serotonin syndrome. Tramadol is available in short- and long-acting formulations and in fixed combination with acetaminophen. The recommended starting dose of oral tramadol is 50 mg 1 or 2 times a day, with gradual titration up to a maximum of 400 mg per day. There is also the option of using tramadol via the rectal or subcutaneous route in patients who are unable to tolerate oral medication

Tramadol is a narcotic-like pain reliever.  Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.  Tramadol may also be used for other purposes not listed in this medication guide.

Tramadol achieves pain relief in two ways. It binds to the opioid receptor on nerves (the same mechanism that is responsible for the effectives of narcotics, such as morphine), and it also inhibits the reuptake of serotonin and norepinephrine by nerves. This inhibition may lead to reduced transmission of pain signals through the spinal cord to the brain.

HOW TO USE Tramadol:

Take this medication by mouth with or without food as directed by your doctor.

The maximum recommended dose is 400 milligrams a day. If you have serious kidney disease (e.g., if you are on dialysis), the maximum recommended dose is 100 milligrams every 12 hours. If you have serious liver disease (e.g., cirrhosis), the maximum recommended dose is 50 milligrams every 12 hours. If you are older than 75 years, the maximum recommended dose is 300 milligrams a day.

Tramadol works best if they are used as the first signs of pain (or migraine) occur. If you wait until the pain has worsened, the medication may not work as well.

Tramadol Risk:

This medication may cause dependence, especially if it has been used regularly for an extended time or if it has been used in high doses. In such cases, withdrawal reactions (e.g., anxiety, sweating, sleeplessness, shaking, diarrhea, rapid breathing) may occur if you suddenly stop this drug. To prevent withdrawal reactions when stopping extended, regular treatment with this drug, gradually reduce the dosage as directed. Also, if you are taking regular doses of narcotic medications for ongoing pain (e.g., cancer pain), starting tramadol may cause a withdrawal reaction. Consult your doctor or pharmacist for more details, and report any withdrawal reactions immediately.

Rarely, abnormal drug-seeking behavior (addiction) is possible with this medication. Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.

Tramadol Side effects

Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, headache, or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you are taking tramadol regularly, it may be useful to start using a laxative right away instead of waiting until you become constipated. Consult your pharmacist for details regarding the correct use of laxatives (e.g., stimulant-type with stool softener).  This medication may rarely cause a very serious condition called serotonin syndrome. The risk increases when this medication is used with certain other drugs (see Drug Interactions section).

Taking Tramadol PRECAUTIONS:

Before taking tramadol, tell your doctor or pharmacist if you are allergic to it; or to other narcotics (e.g., codeine); or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., respiratory depression, hypercapnia), intoxication with drugs that depress the nervous system or your breathing (CNS/respiratory depressants such as alcohol or tranquilizers/sedatives).

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Patients comments on Tramadol usage and satisfaction

Comment 1:

After serious injury to my lower back following a major auto accident I was initially prescribed percocet & valium to help me deal with chronic pain & muscle spasms. After 3 operations & 16-months of physical therapy I was ready to return to work despite my disability. Unfortunately narcotic medication & work do not mix as it is impossible to function clearly and effectively under the influence of these drugs. I have been taking ultram/ tramadol for about 12-years now with great success. I take 2-tabs 2x per day & have found it reduces my pain to a tolerable level and it allows me to function normally without the drug induces haze of a narcotic. As a professional engineer this is not only important, it’s essential. On occasion I still need to take a vicodin & soma when the pain gets the most severe, but for the most part ultram/ tramadol along with proper exercise has allowed me to return to a near normal life & succeed professionally.

Comment 2:

Was prescribed after knee surgery. Worked somewhat, but developed a dependency on it and higher doses, followed by an increase in eosinophil count 225% above normal range. Would not reccommend by any means. Stick with OTC pain medications or a doctor’s reccommendation other than Tramadol.

Comment 3 (Condition: Disorder characterized by Stiff, Tender & Painful Muscles):

I have taken this medication for four years with minimal problems. Some insomnia at first, but it cleared after several weeks and the pain relief has been great. I take 1 table twice per day. In addition I do other things like exercise, stretches, etc. No one pill can do it all. I am pleased with the results and have not found it addicting.

Comment 4: Condition: Neuropathic Pain

I take paroxetine. I take Nexium. I take Trazadone…and I take Tramadol. I have Chronic stenosis of the back. Now I have a neuropathy called CIDP. Now, I know that this medication takes away from the effectiveness of Paroxetine. When I get up in the morning and take it with the Paroxetine, I get a burst of energy, and I am like this all day and at night to turn it off, I have to take Trazadone, and sometimes ambien. I forgot I take requip the generic form for restless leg. Lately I find doing miner things makes me out of breath.

Comments Condition: Pain

It has worked very well, especially when I couple it with 2 Extra Strength Aceteminophen. The pain doesn’t completely go away, but it is tolerable.

Comment 5: Condition: Pain

I have used this medication for a long time and I do believe that it does work on certain pains but it wont help if you have any extra pains. Please note that this is highly addictive if you take large doses or take it everyday consistently. My brother in law had taken it for 2 years and he is taking 20 of them a day now. And when he started he was only taking 4-5 of them. I have been taking it for longer than he has and I still aint taken no more than 6 a day even in my highest usage.

Comment 6 Condition: Pain

They say this drug is useful which it is but i have been told they are non narcotic which is cool but i have seen two of my family members go downhill from this tramadol and now they are addicted to it when one of them tried to get off of this no rehab would help them because they were Not narcotic

Comment 7: Condition: Pain

addictive, brutal withdrawal=insomnia + restless legs, agitation!! but yes it works better than most narcs for me. and it’s not a narc and is relatively transparent. the problem comes(probably like most pain meds) when it’s effectivness decreases and you up dosage. and then you need to back off so as not to take too much. and you end up in a kind of hot/cold cycle. well, maybe just a warm/cold cycle. be careful, though. doctors hand it out like candy just because of it’s no narc rating.