Posts Tagged ‘Corticosteroids’

Gout Medication Treatments And Their Side Effects

April 30th, 2010
Lee Dobbins asked:




One of the most effective ways of reducing the symptoms of a gout attack is through medication. Medications are necessary not just to relieve the pain of acute attacks but also to prevent attacks from recurring. Some gout medications can also target high levels of uric acid in the blood, a condition referred to as hyperuricemia.

To successfully treat gout, it is better to consult a doctor than try to alleviate symptoms through self-medication. Tests will be performed to determine the level of uric acid in the body which might include a urine test or taking a sample of fluid from the affected joint. Once the presence of gout is determined, only then will the course of therapy or medications should be discussed.

Some of the most common medications used to treat gout are:

NSAIDs and corticosteroids

Probably the most common medications used to treat gout are NSAIDs or non-steroidal anti-inflammatory drugs, which are taken orally. As their name implies, NSAIDs function to reduce the swelling in the affected joints and reduce pain.

NSAIDs also block the production of a substance called prostaglandin, which is responsible for causing inflammation and the feeling of pain. Initially, NSAIDs are taken in high doses for as long as symptoms last and medication may continue for about three more days after symptoms have subsided.

It is worth noting, however that while NSAIDs are effective in reducing the inflammation in the joints caused by uric acid crystals, they do not decrease the amount of uric acid found in the body. An NSAID will not, by itself, eliminate uric acid.

Corticosteroids may be prescribed if a patient does not respond to an NSAID or if it is not well tolerated. Corticosteroids are also anti-inflammatory medications and can produce immediate relief if injected directly into the joint. The only drawback is that it cannot be used on a regular basis (i.e., for every attack) because it can cause the weakening of cartilage and promote the deterioration of the joints.

In some cases where symptoms cannot be alleviated or controlled by NSAIDs or corticosteroids, a drug called colchicines may be prescribed during the first 12 hours of a gout attack and is usually taken every hour. It does have side effects, though, such as diarrhea, nausea, abdominal cramps and vomiting.

Gout medications such as probenecid and allopurinol may be prescribed to regulate the levels of uric acid in the blood and are often prescribed to older patients. These medications prevent the development of tophi which are chalk-colored lumps found under the skin, usually around joints.

Another medication that has a long history with gout is colchicine. It has been around since the 1800s and can significantly reduce swelling and relieve pain as well as stop future attacks. It has enjoyed a certain staying power because of its effectiveness. However, its use can cause certain side effects such as vomiting, nausea and diarrhea even when used during a short period.

Other than probenecids, colchicines and allopurinol, sulfinpyrazone may also be prescribed for the treatment of tophi and the prevention of further attacks.

Watching the side effects

Gout medications do have their side effects and can range from mild nausea or dizziness to abdominal cramps and headaches. If you do suffer from these, there is no need to grin and bear it just to get relief later. You can talk to your doctor about it and ask for alternatives. By no means should you stop taking your medications without talking to your doctor first.

Supplements and quack medications

Gout sufferers are often advised to take dietary supplements such as Vitamins E, B-complex and folic acid to replenish the body’s supply. There are also some very attractive and tempting ads making the rounds in the internet and the papers, promising a ‘total cure’ or a ‘miraculous treatment’ for gout.

Before giving in to these ads, it is better to consult with your doctor first. Some of these medications and supplements may not contain harmful ingredients, but they may mix with your current medication and affect your body adversely.

Further research

No cure has yet been discovered for gout, but scientists continue to conduct research on the subject, specifically on the effectiveness of other medications with newer compounds that are safe to use. Studies on the structure of the enzymes involved in breaking down purines inside the body are also being done, to promote further understanding of how these enzymes affect or promote the occurrence of gout.

Migraine

Prescription Arthritis Drugs – Worth the Risk?

February 11th, 2010

If you’re reading this, you’re probably already aware of the dangers associated with prescription arthritis drugs. But it never hurts to have all of the facts, so let’s arm ourselves with some information on many of the most common arthritis drugs and their potential side effects.

Steroids

Steroids have been around since the discovery of cortisone in the 1950′s. Corticosteroids like Prednisone are synthetic drugs that decrease inflammation in the body by mimicking the action of the natural hormone cortisol. There are times that steroids are necessary in order to reduce inflammation that threatens to damage an organ like your heart or kidneys.

However steroids do have some debilitating potential side effects and the higher the dose, the greater the risk. Here’s just a few…

Insomnia

Acne

Eye damage (cataracts, glaucoma, blurred vision)

High blood pressure

Puffy, swollen face

Weight gain and hunger

Mood swings

Restlessness and anxiety

Osteoporosis (brittle bones) and bone loss

Decreased resistance to infections

If you already have osteoporosis or thinning bones, steroids could make it even worse. If your immune system is depressed by steroid use, you’re more likely to catch a cold or flu. You could also develop an infection like pneumonia. But if you’re suffering from rheumatoid arthritis, you already have a malfunctioning immune system! It doesn’t need the further assault of a high steroid dose.

If you find steroids less than enchanting, let’s consider NSAIDs…

NSAIDs (non-steroidal anti-inflammatories) came on to the scene with a lot of fanfare because they contained no steroids. They work by suppressing an enzyme that helps the body produce prostaglandins.

Certain types of prostaglandins are responsible for the pain and swelling of diseases like arthritis, so it would make sense to have less of them, right?

Problem is, prostaglandins serve other functions in the body. They protect your stomach lining. Without them, you could develop an ulcer. Even ordinary aspirin can cause your stomach to bleed if you take enough of it!

Heartburn, indigestion, vomiting, and diarrhea are also common side effects of NSAIDs. So what’s to be done now?

1999 saw the “new and improved” NSAIDs being released. They were supposed to be the perfect answer for patients seeking long-term pain relief.

COX-2 Inhibitors have fewer gastrointestinal side effects, so they were considered a safer alternative. Truly a great discovery for the new century!

Or at least until we learned that the most popular drug in the group, Vioxx (rofecoxib) increases our risk of heart attack and stroke. This was actually discovered in 2000, but it wasn’t until 2004 that Vioxx disappeared from the shelves. Patients are still suing the manufacturer for damages.

The future will probably see the release of newer, and hopefully safer arthritis drugs. No doubt the claims will be loud and long and maybe, this time, they’ll be justified.

However until medicine starts to look at the human body as a whole, we’ll continue to have these sorts of problems. Isolating a set of symptoms and trying to eliminate them, without addressing the root cause of the disease, can only create more problems than it solves.



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Gout Medication Treatments And Their Side Effects

February 9th, 2010

One of the most effective ways of reducing the symptoms of a gout attack is through medication. Medications are necessary not just to relieve the pain of acute attacks but also to prevent attacks from recurring. Some gout medications can also target high levels of uric acid in the blood, a condition referred to as hyperuricemia.

To successfully treat gout, it is better to consult a doctor than try to alleviate symptoms through self-medication. Tests will be performed to determine the level of uric acid in the body which might include a urine test or taking a sample of fluid from the affected joint. Once the presence of gout is determined, only then will the course of therapy or medications should be discussed.

Some of the most common medications used to treat gout are:

NSAIDs and corticosteroids

Probably the most common medications used to treat gout are NSAIDs or non-steroidal anti-inflammatory drugs, which are taken orally. As their name implies, NSAIDs function to reduce the swelling in the affected joints and reduce pain.

NSAIDs also block the production of a substance called prostaglandin, which is responsible for causing inflammation and the feeling of pain. Initially, NSAIDs are taken in high doses for as long as symptoms last and medication may continue for about three more days after symptoms have subsided.

It is worth noting, however that while NSAIDs are effective in reducing the inflammation in the joints caused by uric acid crystals, they do not decrease the amount of uric acid found in the body. An NSAID will not, by itself, eliminate uric acid.

Corticosteroids may be prescribed if a patient does not respond to an NSAID or if it is not well tolerated. Corticosteroids are also anti-inflammatory medications and can produce immediate relief if injected directly into the joint. The only drawback is that it cannot be used on a regular basis (i.e., for every attack) because it can cause the weakening of cartilage and promote the deterioration of the joints.

In some cases where symptoms cannot be alleviated or controlled by NSAIDs or corticosteroids, a drug called colchicines may be prescribed during the first 12 hours of a gout attack and is usually taken every hour. It does have side effects, though, such as diarrhea, nausea, abdominal cramps and vomiting.

Gout medications such as probenecid and allopurinol may be prescribed to regulate the levels of uric acid in the blood and are often prescribed to older patients. These medications prevent the development of tophi which are chalk-colored lumps found under the skin, usually around joints.

Another medication that has a long history with gout is colchicine. It has been around since the 1800s and can significantly reduce swelling and relieve pain as well as stop future attacks. It has enjoyed a certain staying power because of its effectiveness. However, its use can cause certain side effects such as vomiting, nausea and diarrhea even when used during a short period.

Other than probenecids, colchicines and allopurinol, sulfinpyrazone may also be prescribed for the treatment of tophi and the prevention of further attacks.

Watching the side effects

Gout medications do have their side effects and can range from mild nausea or dizziness to abdominal cramps and headaches. If you do suffer from these, there is no need to grin and bear it just to get relief later. You can talk to your doctor about it and ask for alternatives. By no means should you stop taking your medications without talking to your doctor first.

Supplements and quack medications

Gout sufferers are often advised to take dietary supplements such as Vitamins E, B-complex and folic acid to replenish the body’s supply. There are also some very attractive and tempting ads making the rounds in the internet and the papers, promising a ‘total cure’ or a ‘miraculous treatment’ for gout.

Before giving in to these ads, it is better to consult with your doctor first. Some of these medications and supplements may not contain harmful ingredients, but they may mix with your current medication and affect your body adversely.

Further research

No cure has yet been discovered for gout, but scientists continue to conduct research on the subject, specifically on the effectiveness of other medications with newer compounds that are safe to use. Studies on the structure of the enzymes involved in breaking down purines inside the body are also being done, to promote further understanding of how these enzymes affect or promote the occurrence of gout.



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